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Condensation Reaction

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Condensation Reaction

A condensation reaction is a type of chemical reaction in which monomers (small molecules) join together to form polymers (large molecules or macromolecules).

During condensation, covalent bonds form between monomers, allowing them to join together into polymers. As these bonds form, water molecules are removed (or lost).

You might come across another name for condensation: dehydration synthesis.

Dehydration means to remove water (or loss of water - think what happens when you say you are dehydrated). Synthesis in biology refers to the creation of compounds (biological molecules).

In all likelihood, you have come across condensation in chemistry concerning the change of the physical states of matter - gas into liquid - and most commonly, the water cycle study. Yet condensation in biology doesn't mean that biological molecules turn from gases into liquids. Instead, it means the chemical bonds between molecules form with the elimination of water.

What is the general equation of a condensation reaction?

The general equation of condensation goes as follows:

A and B are stand in symbols for the molecules that are condensed, and AB stands for the compound produced from the condensation.

What is an example of a condensation reaction?

Let's use the condensation of galactose and glucose as an example.

Glucose and galactose are both simple sugars - monosaccharides. The result of their condensation reaction is lactose. Lactose is also a sugar, but it is a disaccharide, meaning that it consists of two monosaccharides: glucose and galactose. The two are linked together with a chemical bond called a glycosidic bond (a type of covalent bond).

The formula for lactose is , and galactose and glucose is .

The formula is the same, but the difference is in their molecular structures. Pay attention to the placement of the -OH on the 4th carbon atom in Figure 1.

Figure 1

If we remember the general equation of condensation, it goes as follows:

Now, let us swap A and B (groups of atoms) and AB (a compound) with galactose, glucose, and lactose formulas, respectively:

Notice that both molecules of galactose and glucose have six carbon atoms (C6), 12 hydrogen atoms (H12), and six oxygen atoms (O6).

As a new covalent bond forms, one of the sugars loses a hydrogen atom (H), and the other loses a hydroxyl group (OH). From these, a molecule of water is formed (H + OH = H2O).

Since a water molecule is one of the products, the resulting lactose has 22 hydrogen atoms (H22) instead of 24 and 11 oxygen atoms (O11) instead of 12.

The diagram of condensation of galactose and glucose would look like this:

Figure 2

The same thing happens during other condensation reactions: monomers join to form polymers, and covalent bonds form.

Therefore, we can conclude that:

  • A condensation reaction of monomers monosaccharides forms covalent glycosidic bonds between these monomers. In our example above, disaccharide forms, meaning two monosaccharides join together. If multiple monosaccharides join together, a polymer polysaccharide (or complex carbohydrate) forms.

  • The condensation reaction of monomers that are amino acids results in polymers called polypeptides (or proteins). The covalent bond formed between amino acids is a peptide bond.

  • The condensation reaction of monomers nucleotides forms a covalent bond called a phosphodiester bond between these monomers. The products are polymers called polynucleotides (or nucleic acids).

Although lipids are not polymers (fatty acids and glycerol are not their monomers), they form during condensation.

  • Lipids form in a condensation reaction of fatty acids and glycerol. The covalent bond here is called an ester bond.

Note that condensation reaction is the opposite of hydrolysis reaction. During hydrolysis, polymers are not made as in condensation but broken down. Also, water is not removed but added in a hydrolysis reaction.

What is the purpose of a condensation reaction?

The purpose of a condensation reaction is the creation of polymers (large molecules or macromolecules), such as carbohydrates, proteins, lipids, and nucleic acids, all of which are essential in living organisms.

They are all equally important:

  • Condensation of glucose molecules allows for creating complex carbohydrates, for instance, glycogen, which is used for energy storage. Another example is the formation of cellulose, a carbohydrate that is the main structural component of cell walls.

  • The condensation of nucleotides forms nucleic acids: DNA and RNA. They are crucial for all living matter as they carry genetic material.

  • Lipids are essential energy storage molecules, building blocks of cell membranes and providers of insulation and protection, and they form in the condensation reaction between fatty acids and glycerol.

Without condensation, none of these essential functions would be possible.

Condensation Reaction - Key takeaways

  • Condensation is a chemical reaction during which monomers (small molecules) join to form polymers (large molecules or macromolecules).

  • During condensation, covalent bonds form between monomers, which allow monomers to join together into polymers. Water is released or lost during condensation.

  • Monosaccharides galactose and glucose covalently bond to form lactose, a disaccharide. The bond is called a glycosidic bond.

  • Condensation of all monomers results in the formation of polymers: monosaccharides covalently bond with glycosidic bonds to form polymers polysaccharides; amino acids covalently bond with peptide bonds to form polymers polypeptides; nucleotides covalently bond with phosphodiester bonds to form polymers polynucleotides.

  • The condensation reaction of fatty acids and glycerol (not monomers!) results in the formation of lipids. The covalent bond here is called the ester bond.

  • The purpose of a condensation reaction is the creation of polymers that are essential in living organisms.

Frequently Asked Questions about Condensation Reaction

Condensation is a chemical reaction during which monomers (small molecules) covalently bond to form polymers (large molecules or macromolecules).

In a condensation reaction, covalent bonds form between monomers, and as these bonds form, water is released. This all results in the formation of polymers.

In a condensation reaction, covalent bonds between monomers form, while in hydrolysis, they break. Also, water is removed in condensation while it is added in hydrolysis. The result of condensation is a polymer, and of hydrolysis is the breaking down of a polymer into its monomers.

Condensation is a chemical reaction because chemical bonds are formed between monomers when forming polymers. Also, it is a chemical reaction because monomers (reactants) convert into a different substance (product) that is a polymer.

Condensation polymerisation is the joining of monomers to form polymers with releasing a by-product, usually water. It is different from addition polymerisation, which creates no by-products other than a polymer when monomers join.

Final Condensation Reaction Quiz

Question

What is the definition of condensation in biology?

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Answer

Condensation is a chemical reaction during which monomers (small molecules) covalently bond to form polymers (large molecules or macromolecules).


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Question

What happens with water during condensation?

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Answer

Water is released (lost) during condensation.

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Question

What happens during the condensation of galactose and glucose?

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Answer

Lactose forms and water is lost.

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Question

What polymers form during a condensation reaction of monosaccharides?

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Answer

Polysaccharides

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Question

What is the name of the covalent bond that forms between monosaccharides during condensation?

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Answer

A glycosidic bond

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Question

In one condensation reaction, the result is a polymer called a polypeptide. What are its monomers called?


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Answer

Amino acids

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Question

What is the name of the covalent bond that forms between amino acids during condensation? 


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Answer

A peptide bond

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Question

What polymers form during a condensation reaction of nucleotides?

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Answer

Polynucleotides

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Question

What is the name of the covalent bond that forms between nucleotides during condensation?

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Answer

A phosphodiester bond

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Question

Even though they are not polymers, and their building blocks fatty acids and glycerol are not monomers, lipids form in a condensation reaction.

True or False


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Answer

True. Lipids still form during a condensation reaction of fatty acids and glycerol. 

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Question

What is the purpose of condensation?

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Answer

The purpose of a condensation reaction is the creation of polymers that are large, essential biological molecules.

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Question

Why is the condensation of nucleotides significant?

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Answer

During condensation of nucleotides, the nucleic acids DNA and RNA form. They are crucial for all living matter as they carry genetic material. Without condensation, this vital function would not be possible. 


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Question

Why is the condensation of fatty acids and glycerol significant? Fill in the gaps.

The condensation of fatty acids and glycerol is significant because _____ form as a result. ______ are essential energy________ molecules, building blocks of _____ _________ and providers of insulation and _________. Without condensation, these vital functions would not be possible.

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Answer

The condensation of fatty acids and glycerol is significant because lipids form as a result. Lipids are essential energy storage molecules, building blocks of cell membranes and providers of insulation and protection. Without condensation, these vital functions would not be possible.

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