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Linkage

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Biology

When genes are only present on one sex chromosome, they are referred to as being sex-linked.

Sex linkage in genetics

All humans have 22 autosomal chromosomes (any chromosome that is not a sex chromosome) pairs and one pair of sex chromosomes. Biological females have two X chromosomes and biological males have one X and one Y chromosome.

The process of meiosis produces haploid cells. These only contain a single set of unpaired chromosomes. This means that for females, all gametes will have one X chromosome, while half of the alleles that a male produces will have an X chromosome and half will have a Y chromosome.

Recall that a child will inherit one sex chromosome from their mother and one from their father. Because of this, a child inheriting two X chromosomes (XX) will be biologically female, whereas a child inheriting one X and one Y chromosome (XY) will be biologically male.

Autosomal chromosome: any chromosome that is not a sex chromosome.

Linkage x and y chromosomes StudySmarter

Figure 1. X and Y chromosomes - Finty Royle - StudySmarter Originals

The X chromosome is much longer than the Y chromosome, and most regions of the X chromosome do not have a homologue in the Y chromosome. This means that a single recessive allele on the non-homologous portion of the X chromosome is enough for the corresponding trait to be expressed. After all, there can be no dominant allele on the Y chromosome to mask it. Because of this, the sex of an individual greatly affects their chances of inheriting certain recessive alleles or defective genes which lead to disease.

A homologous pair of chromosomes consists of two chromosomes with the same sequence of genes, loci, and length. One chromosome comes from the mother, and the other from the father. A homologue, therefore, refers to the corresponding chromosome in a homologous pair.

For females, there are three possible phenotypes:

  • Neither suffer nor carry the disease (what is designated as ‘normal’ in some textbooks.)
  • Carrier (has one allele but doesn't suffer the illness.)
  • Has the disease.

For males, there are only two phenotypes:

  • Neither suffer nor carry the disease.
  • Has the disease.

Why can men not be carriers of sex-linked genetic diseases?

Men can’t be carriers of sex-linked genetic diseases because they have only one X chromosome. The Y chromosome is not a homologous chromosome. Therefore, the genetic make-up of the trait isn’t twofold.

Can males be carriers of diseases?

A carrier for a disease has the allele for a trait but doesn’t usually show symptoms. They will be heterozygous (e.g. Aa or Hh) and can pass the allele for the disorder to their offspring. If the offspring is homozygous-recessive (aa or hh) then the offspring will be infected. Males only have one X chromosome. A single recessive gene on that X chromosome will be expressed in the phenotype because there are no corresponding genes on the Y chromosome. This means males cannot be carriers.

In women, a recessive allele on an x chromosome is usually masked in their phenotype by a dominant allele on the other X chromosome. This is why women are more likely to be carriers and not have the gene expressed in their phenotype.

How can we predict the inheritance of colour blindness?

Some of the genes for red-green colour blindness are sex-linked and found on the X chromosome. Let the allele B represent healthy vision and b represent colour blindness. The capital (B in this case) always denotes the dominant allele and lower case (b) denotes the recessive allele.

Dominant allele: an allele that is always expressed, even if the individual only has one copy of it.

Recessive allele: an allele that is only expressed if the individual has two copies of it and does not have the dominant allele of that gene.

The following diagram shows how two healthy parents (a healthy male and a carrier female) can have offspring with colour blindness. As the Y chromosome does not have either gene it is just represented as Y.

Parent’s phenotypes: normal vision normal vision

Parent’s genotypes: Xᴮ Xᵇ XᴮY

Gametes: Xᴮ Xᵇ XᴮY

XᴮXᵇ
XᴮFemale with normal vision XᴮXᴮFemale with normal vision XᴮXᵇ
YMale with normal vision XᴮYColour blind male XᵇY
Figure 2. Inheritance of colour blindness from a healthy father and a carrier mother

50% of offspring will be male, half of whom will be colour blind. This means 25% of offspring are colour blind males. On the other hand, none of the females is colour blind. A colour blind male can only have inherited the condition from his mother since he would have only gained a Y chromosome from his father.

How can we predict the inheritance of haemophilia?

Haemophilia is a disease that affects the blood’s ability to clot.

Haemophilia can lead to slow and persistent internal bleeding, particularly in joints, and can be lethal if left untreated. Because many individuals with this disease do not survive until reproductive age, it is relatively rare. The overwhelming majority of its sufferers today are male; only a small percentage are female. This is in part due to the fact that many haemophiliac females die from extreme blood loss when menstruation begins.

Haemophilia can be caused by a number of things, but one is a recessive allele on the X chromosome which codes for a faulty protein involved in the clotting process. When a carrier female and a healthy male have offspring, 25% will be haemophilic males, as predicted by the diagram below. While males can inherit haemophilia from their mothers, they cannot inherit it from their fathers. 25% of the offspring will also be carriers XᴴXʰ. The following diagram shows a cross between a non-carrier male and a carrier female.

Parent’s phenotypes: Carrier mother Non-carrier father

Parent’s genotypes: XᴴXʰ XᴴY

Gametes: XᴴXʰ XᴴY

Xᴴ
XᴴHealthy female XᴴXᴴCarrier female XᴴXʰ
YHealthy maleXᴴYHaemophilic male XʰY
Figure 3. Inheritance of haemophilia from non-carrier father and carrier mother

Haemophilia is a recessive trait. Thus, non-carrier genotypes are depicted as Xᴴ, while diseased genotypes are depicted as Xʰ.

Pedigree charts

Pedigree charts are a useful method of tracing the inheritance of sex-linked traits. They have specific characteristics such as:

  • Males are represented by squares.
  • Females are represented by circles.
  • The shading in each shape represents the absence or presence of a trait in question – usually the phenotype.
  • Shading indicates the presence of a trait.

The following is an example pedigree of a non-diseased male and a carrier female for the phenotype of colour blindness.

Linkage Pedigree chart StudySmarter

Figure 3. Pedigree chart for the inheritance of colour blindness. Source: Finty Royle - StudySmarter Originals

As shown above, neither parent is colour blind. However, one of the offspring is colour blind. This means that one of the parents is a carrier. Recall that males only have one X chromosome, the female parent must be the carrier.

Autosomal linkage

Autosomal linkage can seem really complicated because there's a lot to think about at once but if we break it down, you’ll see that it's not as hard as it first appears.

  1. Linked genes are genes that occur on the same chromosome.
  2. All the genes on a single chromosome are said to form a linkage group.
  3. Autosomes are all chromosomes except sex chromosomes.
  4. When the same autosome carries two or more genes, we call it autosomal linkage.
  5. These linked genes remain together during meiosis. They pass onto gametes and then offspring together (this is assuming there is no crossing over.)
  6. Segregation in accordance with Mendel's law of independent assortment does not occur.

Mendel's law of independent assortment: different genes are inherited independently of one another.

Genes on the same autosome have a higher chance of being inherited together. Recall that heterozygous individuals possess two different alleles of the same gene. When two genes T and B with heterozygous alleles are on different chromosomes, there would ordinarily be four different combinations, and the offspring would have phenotypes with a 9:3:3:1 ratio (see the article on Inheritance for more details.) However, when genes are linked, there are only two possible combinations: (TB) and (tb), written in brackets to represent linkage. The resulting phenotype ratios are therefore easier to deal with.

Let’s imagine that the gene T controls a plant’s height, where the dominant T produces a tall plant and recessive t produces a short plant. B controls its colour, where dominant B produces red flowers and recessive b produces white flowers. T and B are linked. Assuming no crossing-over, the following is an example of a cross between two individuals that are heterozygous for both genes. Here, we see a 3:1 ratio of phenotypes, which more closely resembles the result of a monohybrid inheritance.

Figure 5. Autosomal linkage between two heterozygous plants. Source: StudySmarter originals

Parental gametesTBtb
TBTTBBTall and redTtBbTall and red
tbTtBbTall and redttbbSmall and white
Figure 6. Autosomal linkage between two heterozygous plants

Linkage - Key takeaways

  • Sex-linked genes are only present on one sex chromosome. When genes are sex-linked, the sex of the individual affects its chances of inheriting a trait.

  • Colour blindness and haemophilia are sex-linked diseases.

  • Males inherit sex-linked diseases more frequently than females. Males only inherit one X chromosome, which means they can only have one of two phenotypes: non-carrier or diseased. Females, on the other hand, inherit two X chromosomes, which means they can be one of: neither suffer nor carry the disease, carrier, or diseased.

  • Autosomal linkage occurs between genes on the same chromosome.

  • When the results of a test cross do not align with those predicted by Mendelian ratios, we can assume that there is a biological reason such as linkage behind it.

Linkage

In biology, the linkage simply means that genes are connected to something in a way that affects their patterns of inheritance. When genes are linked to sex chromosomes, their inheritance depends on the sex of the individual. When they are linked to other genes, they have a higher probability of being inherited together with those genes.

Haemophilia is an example of a disease caused by sex-linked genes. A number of things can cause haemophilia, but one is a recessive allele on the X chromosome, which codes for a faulty protein involved in the blood clotting process. When a carrier female and a non-carrier male have offspring, 25% will be haemophilic males.

There are two types of genetic linkage: autosomal and sex-linkage. In autosomal linkage, genes on the same chromosome will exhibit a tendency to be inherited together. In sex-linkage, genes are only present on one sex chromosome and not the other.

Understanding linkage is vital for understanding how genes are inherited, which can be important for understanding genetic diseases. For instance, linkage can explain unusual or non-Mendelian patterns of inheritance.

There are many ways for genetic linkage to be detected. For instance, test crosses can show that genes are linked. When the cross results do not align with those predicted by Mendelian ratios, we can assume that there is a biological reason behind it.

Final Linkage Quiz

Question

What form of linkage is found on only one type of chromosome?



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Answer

Sex linkage

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Question

Give two examples of sex-linked diseases that are inherited more frequently by males.

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Answer

Colour blindness and haemophilia.

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Question

What is autosomal linkage?

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Answer

Autosomal linkage occurs when two genes on the same chromosome tend to be inherited together.



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Question

In a pedigree chart, which sex is depicted as a square?


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Answer

Male

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Question

In a pedigree chart, which sex is depicted as a circle?


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Answer

Female

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Question

Why are sex-linked genes more likely to be located on the X chromosome than the Y chromosome?



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Answer

The X chromosome is much longer, and most regions of the X chromosome do not have an equivalent homologue in the Y chromosome.



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Question

Male offspring of a carrier mother and a non-diseased father have a ____ chance of inheriting sex-linked diseases.



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Answer

50%

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Question

 Haemophilia is a disease that affect the ______'s ability to _____.



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Answer

blood; clot



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Question

Two heterozygous mice are crossed to identify the pattern of inheritance of two unique traits: weight and fur colour. 


Which of the following offspring phenotype ratios can we expect if the traits of interest exhibited dihybrid inheritance?



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Answer

9:3:3:1



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Question

Two heterozygous mice are crossed to identify the pattern of inheritance of two unique traits: weight and fur colour. 


The resulting offspring have a phenotypic ratio of 3:1, which does not align with predictions for dihybrid inheritance. Suggest a reason why this might have occurred.




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Answer

There was autosomal linkage between the genes.


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Question

Two heterozygous mice are crossed to identify the pattern of inheritance of two unique traits: weight and fur colour. 


 In dihybrid inheritance, alleles are independently assorted, which means there can be ___ different combinations of alleles. However, in autosomal linkage, genes are linked together, which means there can only be ___ combinations of alleles.



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Answer

4, 2

Show question

Question

How many autosomal chromosomes do humans have?

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Answer

22

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Question

A child inheriting _____ _____ chromosomes will be biologically female.

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Answer

two, X

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Question

 a child inheriting _____ ____ and ____ ___ chromosome will be biologically male.

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Answer

one, X, one, Y

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Question

Why can males not be carriers of a disease?

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Answer

A single recessive gene on the X chromosome will not be expressed in the phenotype because there are no corresponding genes on the Y chromosome. This means males cannot be carriers.

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