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# Probabilities in Genetics

Probabilities in Genetics
• Bioenergetics • Biological Molecules • Biological Organisms • Biological Processes • Biological Structures • Biology Experiments • Cell Communication • Cell Cycle • Cell Structure and Function • Cells • Cellular Energetics • Chemistry of Life • Communicable Diseases • Control of Gene Expression • Ecological Levels • Ecology • Ecosystems • Energy Transfers • Genetic Information • Heredity • Microbiology • Organ Systems • Plant Biology • Reproduction • Responding to Change • Substance Exchange While learning about genetics, be prepared to do some math, specifically probabilities. While that may sound intimidating, there's no cause for concern. The mathematics of genetics is pretty straightforward and simplifies the very complex genetic analysis. We can use these for everything from simple garden pea analysis in Mendelian genetics to genetic disorders passed down in families.

## Laws of Probability in Genetics

There are two laws involving calculating probabilities and proportions in genetics. The first is the sum law, and the second is the product law. Let's define them one by one before we use them to examine some problems and cases.

### Key Definitions of Probability in Genetics

The sum law (or sum rule) - To find the probability of two (or more) events occurring, as long as all the events are mutually exclusive (meaning that either one event can happen, or the other can happen, but not both), you must add the probabilities of each individual event occurring together.

The sum law is also known as the "OR" rule. If you see phrases containing the word "or", you should use the sum law. For example, "what is the probability of this OR that occurring?" or "what is the probability of expressing this OR that trait?".

The product law (or product rule) - To find the probability of two (or more) events occurring, as long as all the events are independent of one another (they can all happen at the same time), multiply the probabilities of all individual events occurring.

The product law is also known as the "AND" or "BOTH" rule. When you see phrases containing "and" or "both", you should use the product law. For example, "What is the probability of this AND that occurring?" or "What is the probability of expressing BOTH traits?".

## Application of Probability in Genetics

One of the reasons these mathematical formulae are useful is the Punnett square. It is best used for examining crosses of two alleles at one or a maximum of two genes. If you use a Punnett square to examine this sort of cross: Aa x aa, you will get four boxes to examine the genotypes of offspring. In other words, you will have four squares for a cross at one gene with two possible alleles (Fig. 1). Figure 1: Simple Punnett Square. Chisom, Studysmarter original.

If you use a Punnett square to examine a dihybrid cross: AaBb x AaBb, for example, you'd require 16 boxes to examine the genotypes of offspring (Fig. 2). That is sixteen squares for a cross at two genes with two possible alleles each. Can you see the exponential increase in the number of squares, hence the meticulous work a Punnett square of that size would require? Let's not even imagine how many squares a three-gene cross would need! Figure 2: Dihybrid cross Punnett square. Socratic.

Ultimately, beyond a certain point, Punnett squares are not a feasible option. Therefore, probability and simple mathematics are required. Even for simple, single-gene crosses, probability can be used to double-check our Punnett squares.

### Examples of Probability in Genetics

Let's start with a simple cross of two homozygotes, or pure-breeding, plants. These plants follow the principles of Mendelian inheritance (this is an assumption to make in probability calculations unless stated otherwise), so there is complete dominance, independent assortment, and segregation of alleles.

Please refer to the "Non-Mendelian Genetics" article for a refresher on these concepts.

The tall plants (TT) are dominant over the short plants (ss). Without doing a Punnett square, we know that each parent must have one of their two alleles in their gametes. Because both parents are homozygotes, they only have one type of allele to give. Thus we know that the tall plants must give T alleles and short plants must give s alleles, and the first filial generation has offspring with only one genotype: Ts (Fig. 3). Figure 3: P x P = F1. Bank of Biology.

Now let us continue by crossing two F1 plants together. This kind of cross (F1 x F1) is a monohybrid cross because both plants are hybrid (heterozygous) for the same gene.

Without doing a Punnett square, we know that each parent can give either T or s alleles, and those two alleles can combine with the other parent's allele (Fig. 4). Figure 4: Monohybrid cross. Chisom, Studysmarter Original.

Ts and sT are the same; thus, there are three possible genotypes: TT, Ts, ss. We know the proportions they occur in as well because, for this cross, we get the TT genotype once, the ss genotype once, and the Ts genotype twice.

So the probability of getting a homozygous tall plant: Pr (TT) = 1/4. The probability of getting a heterozygous tall plant: Pr (Tt) = 2/4 = 1/2. The probability of getting a homozygous short plant: Pr (tt) = 1/4.

The two pure-breeding parents are called P generation, and when crossed, their descendants are F1. If the F1 x F1 cross is performed, their descendants are F2. If you cross F2 x F2, their descendants are F3, and so on. Figure 5: F1 x F1 = F2. Bank of biology.

We discovered these probabilities through reasoning (Fig. 5). Now, let's use the sum and product rule to answer further questions. It's important to analyze each part of each question before combining them for your final answer.

• What is the probability of having a tall plant in the F2 generation?
• Tall plants can have TT or Ts genotypes. So we are looking for Pr (TT or Ts).
• We remember that OR in probability signifies addition.
• Therefore, according to the sum rule:
• Pr (TT or Ts) = Pr (TT) + Pr (Ts) = • What is the probability of having two tall offspring in the F2 generation?
• Each offspring has a 3/4 chance to be tall.
• We discovered this in the previous question.
• But, we want two tall offspring this time.
• Wwe need offspring #1 AND offspring #2 to be tall. This is Pr (TT or Ts) AND Pr (TT or Ts)
• Therefore, according to the product rule:
• Pr (tall) x Pr (tall) = • What is the probability of having one short and one tall offspring in the F2 generation?
• We know each offspring has Pr (tall) = 3/4.
• Because there are only two possible phenotypes for this trait, to find the probability of short offspring, we simply do:
• Pr (short) = 1 - Pr (tall) = • We need to find Pr (short) AND Pr (tall), which means multiplication.
• Therefore according to the product rule:
• Pr (short) x Pr (tall) = Now, let's look at a more challenging example—the dihybrid cross.

Dihybrids are organisms that are heterozygotes at two different alleles.

Let's use human genetics and traits for this example to demonstrate that this kind of probability analysis is possible in higher organisms. Many genes in human beings do not follow the principles of Mendelian genetics, but here are two that do. The alleles for freckles and for a widow's peak (that unique V-shaped hairline) are dominant at their respective gene loci. Therefore, the alleles for no freckles and no widow's peak (a more rounded or straight hairline) are recessive.

What would happen if two people who are dihybrids for widow's peaks (Ww) and freckles(Ff) traits married and had children? What kind of alleles could they make? What is the possible genetic outcome for their offspring? Let's examine and answer such questions.

Q: What do dihybrids for widow's peaks and freckles look like?

A: They would both have freckles and widow's peaks because they are heterozygotes for those traits, which are dominant.

Q: What are the genotypes for these parents?

A: FfWw for both parents.

Q: Since both parents have the same genotype (for these two traits), they can make the same possible alleles in their gametes. What are these possibilities?

A: Each gamete must contain one allele of each gene; therefore, FW, Fw, fW, and fw are the possible gametes.

Q: What are the possible genetic outcomes for their offspring?

A: Let's use a Punnett square to examine this. For a dihybrid cross, Punnett squares are quite large and unwieldy (16 squares), but we will simplify this with probabilities later. Figure 6: Human Dihybrid cross. Schoolbag.

We can see the possible genotypes and thus the possible phenotypes (Fig. 6). As usual, with a dihybrid cross, the phenotypic ratio is 9:3:3:1, where 9/16 have dominant/dominant phenotypes, 3/16 have dominant/recessive phenotypes, 3/16 have recessive/dominant phenotypes, and 1/16 have recessive/recessive phenotypes.

A dihybrid cross arises when you cross two organisms with genotypes like this: AaBb x AaBb, and gives the phenotypic ratio 9:3:3:1. A monohybrid cross arises when you cross two organisms with genotypes like this: Aa x Aa, and gives the genotypic

ratio 1:2:1.

But we know that, even without a Punnett square, we can determine genetic outcomes for offspring using our probability laws. Let's try this.

• What is the probability these dihybrids have two children with freckles and widow's peaks?
• First, we need to know the probability of having a single child with freckles and a widow's peak.
• This is Pr (FF or Ff) and Pr (WW or Ww)
• From the monohybrid genotypic ratio, we know Pr (FF) = 1/4. Pr (Ff) = 1/2. Pr (WW) = 1/4. Pr (Ww) = 1/2.
• According to the sum and product law, we get: Pr (FF + Ff) x Pr (WW + Ww)
• This is • Remember, this is the probability of having freckles and a widow's peak in a SINGLE child. Let's check the accuracy with the above Punnett square.
• Now, let's find the probability of having two children both with these traits.
• This Pr (freckles and widow's peak) AND Pr (freckles and widow's peak)
• According to the product law, we get: Pr (9/16) x Pr (9/16)
• This is • Even though these are two dominant traits, the odds of both occurring in two children of these same parents is less than 1/3!

## Probabilities in Genetics - Key Takeaways

• There are two key laws of probability in genetics: the sum law and the product law.
• The sum law is also called the OR law, meaning you use it to add two probabilities together when determining probabilities of one OR the other possibility.
• The product law is also called the AND law, meaning you use it to multiply probabilities with each other when determining the probabilities of one AND another possibility.
• Punnett squares are best used for single-gene analysis of traits that obey Mendelian genetics,
• If more complex genetic assessments are required, probabilities and simple mathematics are necessary to help analyze offspring potential genotypes and phenotypes.

Probability in genetics are simple mathematical analysis of proportions to help understand and postulate future inheritance patterns.

Probability is used in genetics to help analyze possible offspring genetic outcomes.

The principles of probability, namely the sum law and the product law, can help to calculate the likelihood of a genotype or phenotype in offspring of a cross.

Probability is important in genetics because it helps us determine genotypic and phenotypic outcomes for future offspring.

Probability helps predict traits by making a mathematical calculation of the likelihood of a traits existence in a given offspring, via the sum law and the product law.

## Final Probabilities in Genetics Quiz

Question

What is the sum law in genetics?

To find the probability of two (or more) events occurring or existing, as long as all the events are mutually exclusive, you must add the probabilities of each individual event occurring together

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Question

What is the product law in genetics?

To find the probability of two (or more) events occurring, as long as all the events are independent of one another, multiply the probabilities of all individual events occurring.

Show question

Question

What word, if seen in a problem, should indicate to you to use the sum law?

Or

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Question

What words, if seen in a problem, should indicate to you to use the product law?

And or Both

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Question

What is the genotypic ratio of a monohybrid cross

1:2:1

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Question

What is the phenotypic ratio of a dihybrid cross?

9:3:3:1

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Question

Practice Problem: Given that the probability of being tall is 1/8, and the probability of being flexible is 1/2, what is the probability of being tall and flexible?

1/16

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Question

Write this mathematically: The probability of Rr or rr

Pr (Rr + rr)

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Question

How many squares do we expect to see for genetic outcomes for offspring of a dihybrid cross?

16

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Question

Practice Problem: If there are only two alleles for strawberry size, Big (B) and small (b), what is the probability that two heterozygotes will produce a "small strawberry" offspring?

Bb x Bb is the cross.

Pr (small) = Pr (bb) = 1/4

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Question

Are Punnett squares better for simple, single gene traits or complex multigene analysis?

Simple, single gene traits

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Question

Can we analyze traits following principles of Mendelian inheritance with.....

All of the above

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Question

What is the definition of a dihybrid organism?

This is an organism that is heterozygous for two different traits.

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Question

If Black coat and Blue eyes is are dominant at their respective alleles in puppies, what would a dihybrid puppy look like?

It would have both dominant traits, black coat and blue eyes.

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Question

Find the probability of FF or Ff AND gg or GG

Let Pr (FF) = 1/4

Pr (Ff) = 1/2

Pr (gg) = 1/4

Pr (GG) = 1/4

(1/4 + 1/2) x (1/4 + 1/4) = 3/4 x 1/2 =

3/8

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Question

What is a Punnett square?

A Punnett square is a diagram in the shape of a square, that has smaller squares encased within it. Each of those small squares contains a genotype that is possible from a cross of two parent organisms

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Question

What is a Punnett square used for?

Punnett squares are used to determine the probability of any given offspring having a given phenotype.

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Question

What is the phenotypic ratio of a monohybrid cross?

3:1

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Question

What is the phenotypic ratio of a dihybrid cross?

9:3:3:1

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Question

How many types of phenotypes should we get from this cross? Aa x aa

Assume Mendelian Inheritance patterns.

2 different phenotypes.

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Question

How many types of genotypes should we get from this cross? Aa x aa

Assume Mendelian Inheritance patterns.

Two different genotypes

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Question

Which genotype can we not get from this cross? Aa x aa

AA

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Question

Which of these is a possible gamete this parent organism can have, with respect to these two genes: AaHH

Assume Mendelian inheritance and no genetic malfunctioning.

AH

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Question

Which of these is a possible gamete this parent organism can have, with respect to these two genes: BbHh

Assume Mendelian inheritance and no genetic malfunctioning.

BH

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Question

What are the possible outcomes of this cross: Hh x HH

HH and Hh offspring

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Question

What percentage of the offspring of this cross: Hh x HH

would exhibit the dominant phenotype?

100% of them

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Question

What percentage of the offspring of this cross: Hh x Hh

would exhibit the dominant phenotype?

75% of them

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Question

What percentage of the offspring of this cross: Hh x Hh

would exhibit the homozygous dominant genotype?

25 % of them

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Question

If two parents express the phenotype of a dominant trait, and one of their children expresses the phenotype of the recessive allele for that trait, what does that tell us about the parent's phenotype?

Both parents are heterozygotes

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Question

What can we use alternatives to Punnett squares if they are too simplistic to calculate probability?

Pedigrees or Product and Sum Rule.

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