Question: Explain the observed trend in the melting points of the following three isomeric alcohols:
The greater symmetry in makes it has a larger melting point than .
The point at which a particular substance transforms from a solid state to a liquid state is the melting point. Numerous factors influence the melting point, and one among them is the pressure.
Isomeric alcohols are alcohols comprising equivalent molecular formulas but differ in their spatial arrangement. An example of isomeric alcohol is 1-butanol and 2-butanol.
The melting point of a particular compound is directly proportional to the surface area and symmetry. An increase in surface area or symmetry increases the melting point of the particular compound.
A branched polymer has a lesser surface area in comparison to unbranched primary alcohol. is branched primary alcohol and is an unbranched primary alcohol.
Hence, the melting point of is higher than .
Because of the greater symmetry in , it has a larger melting point than and .
Question: Aziridines are heterocycles that contain an N atom in a three-membered ring. Like epoxides, aziridines are strained and reactive because the 60° bond angles of the three-membered ring deviate greatly from the theoretical tetrahedral bond angle. One step in the synthesis of the drug oseltamivir (trade name Tamiflu, Section 3.2) involves the conversion of amine X to diamine Y, a reaction that occurs by way of an intermediate aziridine. Draw a stepwise mechanism for the conversion of X to Y. Indicate the structure of the aziridine intermediate, and explain the trans stereochemistry of the two amines in Y
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